Chevrolet Silverado 2500 Weatherstrip & Seals - OEM-Fit Door, Trunk & Window Seals

Stop leaks, drafts, and road noise in your Chevrolet Silverado 2500 with precision-fit replacement weatherstrip and seals designed specifically for your vehicle. Each seal is engineered to match the original profile and mounting groove of your Chevrolet Silverado 2500—restoring a tight, quiet seal around your doors, trunk, hatch, and windows.

Our Chevrolet Silverado 2500 weatherstrip is manufactured from durable, weather-resistant rubber compounds such as EPDM, engineered for an exact OEM-quality fit and finish. These materials resist sunlight, ozone, and chemical exposure while maintaining flexibility across temperature extremes, so your new seals stay soft and pliable instead of cracking or hardening the way factory-original rubber does over time.

Use the Vehicle Selector above to find the correct weatherstrip for your Chevrolet Silverado 2500, or browse below to explore available options. Whether you’re chasing down a stubborn water leak or completing a full restoration, Factory Interiors makes it easy to achieve a tight, factory-quality seal with precision-fit weatherstrip for your Chevrolet Silverado 2500.

2007-2014 Chevrolet Silverado 2500 Driver & Passenger Side Rear Door Opening Weatherstrip

OEM-replacement rear door opening weatherstrip for Chevrolet / GMC. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.

Replaces GM: 22766417

$59.12
• SALE $40.95
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2007-2014 Chevrolet Silverado 2500 Driver & Passenger Side Rear Door Opening Weatherstrip
1999-2002 Chevy Silverado 2500 (GMT800) Rear Outer Belt Weatherstrip

  • Fitment: Driver and Passenger Side -- Rear -- Sold as: 2-Piece Kit
  • OEM-replacement weatherstrip kit for the 1999-2002 Chevrolet Silverado 2500 (GMT800)

$58.53
• SALE $40.95
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1999-2002 Chevy Silverado 2500 (GMT800) Rear Outer Belt Weatherstrip
2007-2014 Chevrolet Silverado 2500 Driver & Passenger Side Front Door Opening Weatherstrip

OEM-replacement front door opening weatherstrip for Chevrolet / GMC. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.

Replaces GM: 22766400

$56.99
• SALE $39.95
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2007-2014 Chevrolet Silverado 2500 Driver & Passenger Side Front Door Opening Weatherstrip
1999-2002 Chevrolet Silverado 2500 Driver & Passenger Side Door Seal

OEM-replacement door seal for Cadillac / Chevrolet / GMC. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.

Replaces GM: 15758703, 15766539, 15956393, 15956394, 15973659

$53.21
• SALE $36.95
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1999-2002 Chevrolet Silverado 2500 Driver & Passenger Side Door Seal
1999-2007 Chevrolet Silverado 2500 Driver & Passenger Side Door Seal

OEM-replacement door seal for Cadillac / Chevrolet / GMC. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.

Replaces GM: 15752299

$45.37
• SALE $31.95
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1999-2007 Chevrolet Silverado 2500 Driver & Passenger Side Door Seal

(30 Total Products)