Ford F-250 Super Duty Weatherstrip & Seals - OEM-Fit Door, Trunk & Window Seals

Stop leaks, drafts, and road noise in your Ford F-250 Super Duty with precision-fit replacement weatherstrip and seals designed specifically for your vehicle. Each seal is engineered to match the original profile and mounting groove of your Ford F-250 Super Duty—restoring a tight, quiet seal around your doors, trunk, hatch, and windows.

Our Ford F-250 Super Duty weatherstrip is manufactured from durable, weather-resistant rubber compounds such as EPDM, engineered for an exact OEM-quality fit and finish. These materials resist sunlight, ozone, and chemical exposure while maintaining flexibility across temperature extremes, so your new seals stay soft and pliable instead of cracking or hardening the way factory-original rubber does over time.

Use the Vehicle Selector above to find the correct weatherstrip for your Ford F-250 Super Duty, or browse below to explore available options. Whether you’re chasing down a stubborn water leak or completing a full restoration, Factory Interiors makes it easy to achieve a tight, factory-quality seal with precision-fit weatherstrip for your Ford F-250 Super Duty.

1999-2016 Ford F-250 Super Duty Driver & Passenger Side Rear Door Seal on Body

OEM-replacement rear door seal on body for the Ford. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.

Replaces Ford: 5C3Z 2625324 AA

$68.54
• SALE $47.95
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1999-2016 Ford F-250 Super Duty Driver & Passenger Side Rear Door Seal on Body
1999-2016 Ford F-250 Super Duty Driver & Passenger Side Rear Lower Door Seal on Door Kit

OEM-replacement rear lower door seal on door kit for the Ford. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.

Replaces Ford: 1C3Z-28253A24-A

$48.94
• SALE $33.95
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1999-2016 Ford F-250 Super Duty Driver & Passenger Side Rear Lower Door Seal on Door Kit
1999-2016 Ford F-250 Super Duty Front Belt Weatherstrip

OEM-replacement belt weatherstrip for the Ford. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.

Replaces Ford: F81Z 2521453 AA

$44.61
• SALE $30.95
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1999-2016 Ford F-250 Super Duty Front Belt Weatherstrip
1999-2016 Ford F-250 Super Duty Rear Belt Weatherstrip

OEM-replacement belt weatherstrip for the Ford. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.

Replaces Ford: F81Z2625596AA

$41.19
• SALE $28.95
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1999-2016 Ford F-250 Super Duty Rear Belt Weatherstrip
1999-2013 Ford F-250 Super Duty Front Belt Weatherstrip

OEM-replacement belt weatherstrip for the Ford. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.

Replaces Ford: F81Z 2521452 AA

$39.92
• SALE $27.95
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1999-2013 Ford F-250 Super Duty Front Belt Weatherstrip

(27 Total Products)