Ford F-250 Weatherstrip & Seals - OEM-Fit Door, Trunk & Window Seals

Stop leaks, drafts, and road noise in your Ford F-250 with precision-fit replacement weatherstrip and seals designed specifically for your vehicle. Each seal is engineered to match the original profile and mounting groove of your Ford F-250—restoring a tight, quiet seal around your doors, trunk, hatch, and windows.

Our Ford F-250 weatherstrip is manufactured from durable, weather-resistant rubber compounds such as EPDM, engineered for an exact OEM-quality fit and finish. These materials resist sunlight, ozone, and chemical exposure while maintaining flexibility across temperature extremes, so your new seals stay soft and pliable instead of cracking or hardening the way factory-original rubber does over time.

Use the Vehicle Selector above to find the correct weatherstrip for your Ford F-250, or browse below to explore available options. Whether you’re chasing down a stubborn water leak or completing a full restoration, Factory Interiors makes it easy to achieve a tight, factory-quality seal with precision-fit weatherstrip for your Ford F-250.

1973-1979 Ford F-250 Driver Side Door Latch Control, LH

OEM-replacement door latch control, lh for the Ford. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.

Replaces Ford: D6OZ6521819A

$49.68
• SALE $34.95
Select Color/Material Options  
1973-1979 Ford F-250 Driver Side Door Latch Control, LH
1967-1972 Ford F-250 Driver & Passenger Side Door Seal Kit - on Body Driver Side & Passenger Side

OEM-replacement door seal kit - on body driver side & passenger side for the Ford. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.

Replaces Ford: C7TZ8120530B

$49.57
• SALE $34.95
Select Color/Material Options  
1967-1972 Ford F-250 Driver & Passenger Side Door Seal Kit - on Body Driver Side & Passenger Side
1961-1966 Ford F-250 Driver & Passenger Side Belt Weatherstrip Kit - Inner & Outer Driver Side & Passenger Side

OEM-replacement belt weatherstrip kit - inner & outer driver side & passenger side for the Ford. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.

$49.46
• SALE $34.95
Select Color/Material Options  
1961-1966 Ford F-250 Driver & Passenger Side Belt Weatherstrip Kit - Inner & Outer Driver Side & Passenger Side
1980-1991 Ford F-250 Passenger Side Door Latch Control, RH

OEM-replacement door latch control, rh for the Ford. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.

Replaces Ford: EOTZ1021818B

1980-1991 Ford F-250 Driver Side Door Latch Control, LH

OEM-replacement door latch control, lh for the Ford. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.

Replaces Ford: EOTZ1021819B

$46.13
• SALE $31.95
Select Color/Material Options  
1980-1991 Ford F-250 Driver Side Door Latch Control, LH

(131 Total Products)