Ford F-250 Weatherstrip & Seals - OEM-Fit Door, Trunk & Window Seals
Stop leaks, drafts, and road noise in your Ford F-250 with precision-fit replacement weatherstrip and seals designed specifically for your vehicle. Each seal is engineered to match the original profile and mounting groove of your Ford F-250—restoring a tight, quiet seal around your doors, trunk, hatch, and windows.
Our Ford F-250 weatherstrip is manufactured from durable, weather-resistant rubber compounds such as EPDM, engineered for an exact OEM-quality fit and finish. These materials resist sunlight, ozone, and chemical exposure while maintaining flexibility across temperature extremes, so your new seals stay soft and pliable instead of cracking or hardening the way factory-original rubber does over time.
Use the Vehicle Selector above to find the correct weatherstrip for your Ford F-250, or browse below to explore available options. Whether you’re chasing down a stubborn water leak or completing a full restoration, Factory Interiors makes it easy to achieve a tight, factory-quality seal with precision-fit weatherstrip for your Ford F-250.
OEM-replacement door seal kit for the Ford. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.
Replaces Ford: F0TZ1520708A
OEM-replacement back window seal - back window for the Ford. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.
Replaces Ford: F6TZ1542084AB
OEM-replacement vent window seal kit for the Ford. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.
Replaces Ford: E0TZ1021448A, E0TZ1021449A, EOTZ1021448A, EOTZ1021449A
OEM-replacement vent window seal kit for the Ford. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.
Replaces Ford: C7TZ8121448A, C7TZ8121449A, C7TZ8122296B, C7TZ8122297B
OEM-replacement belt weatherstrip kit - inner & outer driver side & passenger side for the Ford. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.
Replaces Ford: E7TZ1521452A, E7TZ1521453A, F2TZ1521456A, F2TZ1521457A
(131 Total Products)