GMC 2500 Weatherstrip & Seals - OEM-Fit Door, Trunk & Window Seals

Stop leaks, drafts, and road noise in your GMC 2500 with precision-fit replacement weatherstrip and seals designed specifically for your vehicle. Each seal is engineered to match the original profile and mounting groove of your GMC 2500—restoring a tight, quiet seal around your doors, trunk, hatch, and windows.

Our GMC 2500 weatherstrip is manufactured from durable, weather-resistant rubber compounds such as EPDM, engineered for an exact OEM-quality fit and finish. These materials resist sunlight, ozone, and chemical exposure while maintaining flexibility across temperature extremes, so your new seals stay soft and pliable instead of cracking or hardening the way factory-original rubber does over time.

Use the Vehicle Selector above to find the correct weatherstrip for your GMC 2500, or browse below to explore available options. Whether you’re chasing down a stubborn water leak or completing a full restoration, Factory Interiors makes it easy to achieve a tight, factory-quality seal with precision-fit weatherstrip for your GMC 2500.

1966 GMC 2500 Windshield Weatherstrip Seal, 64-66 GM Full Size Truck, Suburban, Van, With Trim Groove.

Designed for 1964-1966 GM full-size trucks, Suburbans, and vans, this windshield seal is crafted to fit perfectly with models featuring a trim groove. Made from durable EPDM polymer, it ensures a snug and accurate seal profile, reducing drafts and road noise while keeping your cabin comfortable and quiet. This seal is built to withstand the elements, offering long-lasting performance and a clean, professional finish for your windshield installation. It fits a wide range of vehicles, including Chevrolet C10, C20, C30, K10, and K20 pickup trucks, as well as GMC 1000, 1500, 2500, and G1000 series trucks from 1964 to 1966. With its precise design and high-quality material, this seal is an excellent choice for restoring or maintaining your classic truck.

Features and Benefits
  • Reduces drafts and road noise for a quieter ride.
  • Made from durable EPDM polymer for long-lasting use.
  • Designed to fit models with a trim groove for a clean look.
  • Provides a precise seal to protect against the elements.

$132.99
• SALE $106.95
Select Color/Material Options  
1966 GMC 2500 Windshield Weatherstrip Seal, 64-66 GM Full Size Truck, Suburban, Van, With Trim Groove.
1964-1965 GMC 2500 Windshield Weatherstrip Seal, 64-66 GM Full Size Truck, Suburban, Van, With Trim Groove.

Designed for 1964-1966 GM full-size trucks, Suburbans, and vans, this windshield seal is crafted to fit perfectly with models featuring a trim groove. Made from durable EPDM polymer, it ensures a snug and accurate seal profile, reducing drafts and road noise while keeping your cabin comfortable and quiet. This seal is built to withstand the elements, offering long-lasting performance and a clean, professional finish for your windshield installation. It fits a wide range of vehicles, including Chevrolet C10, C20, C30, K10, and K20 pickup trucks, as well as GMC 1000, 1500, 2500, and G1000 series trucks from 1964 to 1966. With its precise design and high-quality material, this seal is an excellent choice for restoring or maintaining your classic truck.

Features and Benefits
  • Reduces drafts and road noise for a quieter ride.
  • Made from durable EPDM polymer for long-lasting use.
  • Designed to fit models with a trim groove for a clean look.
  • Provides a precise seal to protect against the elements.

$132.99
• SALE $106.95
Select Color/Material Options  
1964-1965 GMC 2500 Windshield Weatherstrip Seal, 64-66 GM Full Size Truck, Suburban, Van, With Trim Groove.
1960 GMC 2500 Flexible Window Channel.

This flexible window channel is designed for 1950-1963 Chevrolet and GMC full-size pickup trucks, measuring 60 inches in length. Crafted to provide an accurate seal profile, it ensures a snug fit and smooth operation for your truck's windows. The channel features a durable, flexible design that makes installation straightforward, fitting securely into the window frame to prevent rattling and reduce noise. Its high-quality construction is built to withstand wear and tear, offering long-lasting performance. This part is compatible with a wide range of models, including 1950-1959 Chevrolet and GMC trucks, as well as 1960-1963 Chevrolet C10, C20, and C30 pickups and panels. Backed by a 90-day warranty, this window channel is a reliable choice to restore functionality and comfort to your classic truck.

Features and Benefits
  • Provides a precise seal for smooth window operation.
  • Flexible design ensures easy installation.
  • Reduces noise and prevents window rattling.
  • Built for durability and long-lasting performance.

$147.49
• SALE $117.95
Select Color/Material Options  
1960 GMC 2500 Flexible Window Channel.
1966 GMC 2500 Rigid Division-Bar Channel.

This rigid division-bar channel is designed for classic truck models, including the 1952-1956 Ford F-Series, 1964-1967 Dodge D and W Series, 1965-1967 Chevrolet C and K Series, and 1965-1967 GMC trucks. Measuring 72 inches in length, it features a durable stainless steel bead, a pile lining for a snug fit, and a heavy steel core for long-lasting performance. The channel ensures a precise seal, helping to keep out moisture, dust, and wind, while maintaining the vehicle's original look and functionality. It can be sectioned into two equal lengths for easier overseas shipping, making it versatile for various installation needs. A $20 special shipping charge applies for domestic orders, with additional costs for international shipping. Backed by a 90-day warranty, this part is a reliable choice for restoring or maintaining your classic truck.

Features and Benefits
  • Provides a secure and accurate seal for improved weatherproofing.
  • Made with a heavy steel core for enhanced durability.
  • Stainless steel bead adds corrosion resistance and a clean finish.
  • Can be cut into two sections for easier handling and shipping.

$185.49
• SALE $148.95
Select Color/Material Options  
1966 GMC 2500 Rigid Division-Bar Channel.
1966 GMC 2500 Front Vent Window Weatherstrip Seals W/ Vertical Division Bar.

For 1964-1966 Chevrolet and GMC Pickup Trucks, these front vent window seals with a vertical division bar are precision-engineered to fit perfectly. Measuring 15-11/16" and 26-1/2" in length, this 4-piece set includes seals for both the right and left sides, ensuring a snug and secure fit. Designed using the latest CAD and CNC milling technology, these seals offer a flawless 3D contour that matches OEM quality and appearance. They are crafted to keep out water, wind, and debris, providing long-lasting protection and enhancing the comfort of your truck's cabin. Compatible with 1964-1966 Chevrolet C10, C20, C30, K10, K20, P10 Series, and GMC 1000, 1500, 2500, and K15/K1500 trucks, these seals are a perfect replacement for worn or damaged originals. Backed by Metro's 30-year warranty, you can trust in their durability and performance for decades to come.

Features and Benefits
  • Keeps water and wind out for a quieter ride.
  • Precision fit ensures easy installation and a clean look.
  • Durable materials resist wear and tear over time.

$240.49
• SALE $191.95
Select Color/Material Options  
1966 GMC 2500 Front Vent Window Weatherstrip Seals W/ Vertical Division Bar.

(26 Total Products)