GMC C25/C2500 Weatherstrip & Seals - OEM-Fit Door, Trunk & Window Seals

Stop leaks, drafts, and road noise in your GMC C25/C2500 with precision-fit replacement weatherstrip and seals designed specifically for your vehicle. Each seal is engineered to match the original profile and mounting groove of your GMC C25/C2500—restoring a tight, quiet seal around your doors, trunk, hatch, and windows.

Our GMC C25/C2500 weatherstrip is manufactured from durable, weather-resistant rubber compounds such as EPDM, engineered for an exact OEM-quality fit and finish. These materials resist sunlight, ozone, and chemical exposure while maintaining flexibility across temperature extremes, so your new seals stay soft and pliable instead of cracking or hardening the way factory-original rubber does over time.

Use the Vehicle Selector above to find the correct weatherstrip for your GMC C25/C2500, or browse below to explore available options. Whether you’re chasing down a stubborn water leak or completing a full restoration, Factory Interiors makes it easy to achieve a tight, factory-quality seal with precision-fit weatherstrip for your GMC C25/C2500.

1967-1972 GMC C25/C2500 Glass-Run Channel 36".

Glass Run Channel – 1960–1972 Chevy & GMC Truck Restore the proper seal and quiet ride your classic truck was built to have. This premium glass run channel presses directly into the vertical division bar channel and is designed as a single 36-inch piece that will fit either the driver-side or passenger-side door. Manufactured to precise OEM specifications, it installs just like the original for a clean, factory-authentic appearance. Replacing old, cracked, or dried-out weatherstrip helps keep out wind, water, and road noise.

Features and Benefits
  • Durable, high-quality material resists cracking, shrinking, and wear
  • Made to OEM specifications for a perfect, factory-style fit
  • Provides a secure and quiet fit for windows.

$47.49
• SALE $37.95
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1967-1972 GMC C25/C2500 Glass-Run Channel 36".
1973-1974 GMC C25/C2500 Upper Door Weatherstrip Seals, 73-77 GM Full Size Truck and SUV, Pair.

Designed for 1973-1977 GM full-size trucks and SUVs, these upper door seals (OEM #14013791) are crafted to provide a precise fit and exceptional durability. Made from high-quality EPDM polymer, they are built to withstand harsh weather conditions while effectively reducing drafts and road noise. These seals are engineered to restore the original sealing profile, ensuring a snug fit that keeps your cabin quiet and comfortable. Perfect for Chevrolet and GMC models like the C10, K10, Suburban, and Jimmy, these seals are an essential upgrade for maintaining your vehicle's integrity. With a straightforward installation process, they fit seamlessly onto the upper door frame, offering long-lasting performance. Backed by a 90-day hassle-free warranty, these seals are a reliable choice for restoring your truck or SUV.

Features and Benefits
  • Reduces drafts and road noise for a quieter ride.
  • Made from durable EPDM polymer for long-lasting use.
  • Restores the original sealing profile for a precise fit.
  • Easy installation ensures a hassle-free upgrade.

$60.49
• SALE $48.95
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1973-1974 GMC C25/C2500 Upper Door Weatherstrip Seals, 73-77 GM Full Size Truck and SUV, Pair.
1967-1972 GMC C25/C2500 Window Channel Run-Upper, 67-72 GM Full Size Truck and SUV, Each.

Designed for GM full-size trucks and SUVs from 1967 to 1972, this window channel run-upper fits either the left or right side and replaces OEM #3893719. Crafted from durable EPDM polymer, it ensures a snug, accurate seal to reduce drafts and road noise, enhancing your driving comfort. The part is tailored for a precise fit, making installation straightforward while maintaining the original look and functionality of your vehicle. This channel run is compatible with a wide range of models, including Chevrolet C10, C20, C30, K10, K20, Blazer, Suburban, and GMC C15/C1500, C25/C2500, C35/C3500, and Jimmy trucks from 1967 to 1972. Its robust construction resists wear and tear, ensuring long-lasting performance. Backed by a 90-day warranty, this part is a reliable choice for restoring your vehicle's windows to their best condition.

Features and Benefits
  • Provides a tight seal to block drafts and noise.
  • Made from durable EPDM polymer for longevity.
  • Fits left or right side for versatile installation.
  • Compatible with a wide range of 1967-1972 GM trucks and SUVs.

$69.49
• SALE $55.95
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1967-1972 GMC C25/C2500 Window Channel Run-Upper, 67-72 GM Full Size Truck and SUV, Each.
1967 GMC C25/C2500 Flocked Glass Run Channel.

This flocked glass run channel, measuring 96 inches, is designed for vehicles with framed side glass, ensuring a snug and precise fit. Crafted by Metro Moulded Parts, it features accurate seal profiles that help keep your vehicle’s interior protected from the elements while reducing noise and vibration. This part is compatible with a wide range of 1965-1967 models, including Chevrolet C10, C20, and C30 Pickup Trucks, Chrysler 300, Imperial, and Newport Cars, Dodge Dart, Coronet, and Monaco Cars, GMC 1000 and 1500 Series Trucks, and Plymouth Barracuda, Belvedere, and Fury Cars, among others. Its flocked surface ensures smooth window operation, while the durable construction guarantees long-lasting performance. Backed by a 90-day warranty, this glass run channel is a reliable choice for restoring or maintaining your classic vehicle.

Features and Benefits
  • Provides a tight seal to keep out wind and water.
  • Reduces noise and vibration for a quieter ride.
  • Flocked surface ensures smooth window movement.
  • Durable material offers long-lasting performance.

$82.49
• SALE $65.95
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1967 GMC C25/C2500 Flocked Glass Run Channel.
1974 GMC C25/C2500 Rear Cargo Door Weatherstrip Seal. RH (Passenger's Side).

For full-size vans, this rear cargo door seal fits the RH (passenger's side) and is designed for 1996 early design models. Crafted by SUPERsoft, this seal is 30% softer and more durable than other brands, ensuring a snug and reliable fit that prevents water, dust, and noise from entering your vehicle. Unlike other seals, it is made without accelerants or cheap fillers, which means it resists premature aging and cracking over time. This part is compatible with a wide range of vehicles, including Chevrolet and GMC vans and trucks from 1974 to 1996, such as the Chevrolet G10, G20, and G30 vans, as well as GMC G1500, G2500, and G3500 vans. Its flexible and durable construction makes installation straightforward, providing a tight seal around the cargo door for long-lasting performance. Backed by a 30-year warranty from SUPERsoft, this seal offers peace of mind and exceptional value for your restoration or repair project.

Features and Benefits
  • Provides a tight seal to keep out water, dust, and noise.
  • Made with 30% softer material for easier installation and durability.
  • Free from cheap fillers, ensuring long-lasting performance.

$83.49
• SALE $66.95
Select Color/Material Options  
1974 GMC C25/C2500 Rear Cargo Door Weatherstrip Seal. RH (Passenger's Side).

(24 Total Products)