Ford F-250 Weatherstrip & Seals - OEM-Fit Door, Trunk & Window Seals

Stop leaks, drafts, and road noise in your Ford F-250 with precision-fit replacement weatherstrip and seals designed specifically for your vehicle. Each seal is engineered to match the original profile and mounting groove of your Ford F-250—restoring a tight, quiet seal around your doors, trunk, hatch, and windows.

Our Ford F-250 weatherstrip is manufactured from durable, weather-resistant rubber compounds such as EPDM, engineered for an exact OEM-quality fit and finish. These materials resist sunlight, ozone, and chemical exposure while maintaining flexibility across temperature extremes, so your new seals stay soft and pliable instead of cracking or hardening the way factory-original rubber does over time.

Use the Vehicle Selector above to find the correct weatherstrip for your Ford F-250, or browse below to explore available options. Whether you’re chasing down a stubborn water leak or completing a full restoration, Factory Interiors makes it easy to achieve a tight, factory-quality seal with precision-fit weatherstrip for your Ford F-250.

1973-1979 Ford F-250 Rear Window Weatherstrip Seal, '73-'79 Ford F Series Truck Without Trim Groove.

This weatherstrip does not work with original sliders. For the 1973-1979 Ford F-Series Trucks, this rear window seal is designed specifically for models without a trim groove and does not work with original sliders. Crafted from durable EPDM polymer, it ensures a snug, accurate fit to keep drafts, water, and road noise out of your cab. Proudly made in the USA, this seal is built to last and maintain its flexibility over time, providing reliable performance in all weather conditions. Its precise profile makes installation straightforward, fitting securely around the rear window to restore a clean, factory-like appearance. Compatible with Ford F-100, F-150, F-250, and F-350 trucks from 1973 to 1979, this seal is an essential upgrade for maintaining comfort and protecting your truck’s interior. Backed by a 90-day warranty, it’s a no-hassle solution for a better driving experience.

Features and Benefits
  • Reduces drafts and road noise for a quieter ride.
  • Made from long-lasting EPDM polymer for durability.
  • Fits securely to prevent water leaks and protect the interior.
  • Proudly made in the USA for quality you can trust.

$118.49
• SALE $94.95
Select Color/Material Options  
1973-1979 Ford F-250 Rear Window Weatherstrip Seal, '73-'79 Ford F Series Truck Without Trim Groove.
1997-1999 Ford F-250 Front Door Weatherstrip Seal.

This front door seal is designed for extended cab trucks, fitting on the body for both the front left and right sides. Specifically crafted for 1997-2004 Ford F-150 Trucks, including the 2004 F-150 Heritage model, and 1997-1999 Ford F-250 Trucks, this seal ensures a snug fit to keep out water, wind, and noise. Made by SUPERsoft, it is 30% softer and more durable than other brands, offering a premium feel and long-lasting performance. Unlike other seals, it is manufactured without accelerants or cheap fillers, preventing premature aging or cracking. The seal is easy to install, providing a tight and secure fit to maintain the integrity of your truck’s cabin. Backed by a 90-day warranty, this part is a reliable choice for restoring comfort and protection to your vehicle.

Features and Benefits
  • Keeps water, wind, and noise out for a quieter ride.
  • Made with durable, high-quality materials for long-lasting use.
  • Easy to install for a secure and precise fit.
  • Designed to maintain the cabin’s comfort and protection.

$118.99
• SALE $94.95
Select Color/Material Options  
1997-1999 Ford F-250 Front Door Weatherstrip Seal.
1997-1999 Ford F-250 Door Weatherstrip Seal For Quad Cab.

Designed for the Quad Cab body style, this door seal fits the front left and right sides of the vehicle, ensuring a snug and secure fit. Specifically crafted for 1997-2004 Ford F-150 Trucks, including the 2004 F-150 Heritage model, and 1997-1999 Ford F-250 Trucks, this seal is a perfect replacement for worn or damaged seals. Made by SUPERsoft, it is 30% softer and more durable than other brands, providing a superior seal against wind, water, and noise. Unlike other seals, it is manufactured without accelerants or cheap fillers, which means it resists premature aging and cracking. This high-quality seal is easy to install, fitting seamlessly into the door frame to restore the original factory look and function. Backed by a 90-day warranty, this part ensures peace of mind with its reliable performance.

Features and Benefits
  • Provides a tight seal to block wind, water, and noise.
  • Made from durable, long-lasting materials for extended use.
  • Easy to install for a hassle-free replacement.
  • Designed to fit perfectly on 1997-2004 Ford F-150 and 1997-1999 Ford F-250 Trucks.

$132.49
• SALE $105.95
Select Color/Material Options  
1997-1999 Ford F-250 Door Weatherstrip Seal For Quad Cab.
1961-1966 Ford F-250 Door Weatherstrip Seal, 61-66 Ford Full Size Pickup Trucks, On Body, Pair.

For 1961-1966 Ford full-size pickup trucks, this pair of on-body door seals is designed to provide a precise fit and exceptional performance. Crafted from durable EPDM polymer, these seals feature an accurate profile that ensures a snug fit, effectively reducing drafts and road noise for a quieter and more comfortable ride. Unlike solid sponge-type seals, these are hollowed out to allow your doors to close effortlessly without added resistance. These seals are specifically engineered for models including the Ford F-100, F-250, F-350, F-500, F-600, F-700, F-750, F-800, F-850, F-950, N-Series, NT-Series, and T-Series trucks from 1961 to 1966. Easy to install, they mount directly onto the body of your truck, restoring a tight seal that keeps out wind, water, and debris. Backed by a 90-day hassle-free warranty, this product ensures peace of mind with every purchase.

Features and Benefits
  • Reduces drafts and road noise for a quieter cabin.
  • Hollow design ensures doors close smoothly.
  • Made from durable EPDM polymer for long-lasting performance.
  • Easy installation directly onto the truck body.

$138.49
• SALE $110.95
Select Color/Material Options  
1961-1966 Ford F-250 Door Weatherstrip Seal, 61-66 Ford Full Size Pickup Trucks, On Body, Pair.
1977-1979 Ford F-250 Windshield Weatherstrip Seal with Trim Groove 77-79 Ford F Series Truck 78-79 Ford Bronco.

Designed for the 1977-1979 Ford F-Series Trucks and 1978-1979 Ford Bronco, this windshield seal with Trim Groove is crafted to provide a precise fit and exceptional durability. Made from high-quality EPDM polymer, it features a groove to securely accept trim, ensuring a clean and professional finish. This seal is engineered to reduce drafts and road noise, enhancing the comfort of your ride. Its accurate profile ensures a snug fit, making installation straightforward while maintaining a tight seal to keep out water and debris. Whether you're restoring a classic or maintaining your vehicle, this seal is a reliable choice for keeping your windshield secure and your cabin quiet.

Features and Benefits
  • Made from durable EPDM polymer for long-lasting performance.
  • Reduces drafts and road noise for a quieter ride.
  • Features a groove to accept trim for a clean, finished look.
  • Designed for easy installation with an accurate seal profile.

$173.99
• SALE $138.95
Select Color/Material Options  
1977-1979 Ford F-250 Windshield Weatherstrip Seal with Trim Groove 77-79 Ford F Series Truck 78-79 Ford Bronco.

(131 Total Products)