Ford F-250 Weatherstrip & Seals - OEM-Fit Door, Trunk & Window Seals

Stop leaks, drafts, and road noise in your Ford F-250 with precision-fit replacement weatherstrip and seals designed specifically for your vehicle. Each seal is engineered to match the original profile and mounting groove of your Ford F-250—restoring a tight, quiet seal around your doors, trunk, hatch, and windows.

Our Ford F-250 weatherstrip is manufactured from durable, weather-resistant rubber compounds such as EPDM, engineered for an exact OEM-quality fit and finish. These materials resist sunlight, ozone, and chemical exposure while maintaining flexibility across temperature extremes, so your new seals stay soft and pliable instead of cracking or hardening the way factory-original rubber does over time.

Use the Vehicle Selector above to find the correct weatherstrip for your Ford F-250, or browse below to explore available options. Whether you’re chasing down a stubborn water leak or completing a full restoration, Factory Interiors makes it easy to achieve a tight, factory-quality seal with precision-fit weatherstrip for your Ford F-250.

1953-1955 Ford F-250 Vent Window Weatherstrip Seals. Pair R&L.

For 1953-1955 Ford F-100, F-250, F-350 Trucks and 1954-1955 Ford Courier Sedan Delivery Trucks, these vent window seals are precision-engineered to fit perfectly, ensuring a snug and secure seal for your vehicle's vent windows. Designed using the latest advancements in CAD and CNC milling, these seals offer a precise 3D contour that matches the original OEM appearance, enhancing both functionality and aesthetics. Crafted to keep out water, wind, and debris, they provide excellent weatherproofing, protecting your interior from the elements while reducing noise. Installation is straightforward, as these seals are made to fit seamlessly into the vent window frame, restoring the original look and performance of your classic truck. Backed by Metro's 30-year warranty, you can trust in their durability and long-lasting quality.

Features and Benefits
  • Provides a tight seal to block water, wind, and debris.
  • Enhances the appearance of your classic truck with OEM-quality design.
  • Easy installation with precise 3D contouring for a perfect fit.

$189.49
• SALE $151.95
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1953-1955 Ford F-250 Vent Window Weatherstrip Seals. Pair R&L.
1967-1979 Ford F-250 Windshield Weatherstrip Seal, 67-79 Ford Full Size Truck, 78-79 Bronco, Without Trim Groove.

Designed for 1967-1979 Ford F-Series Trucks and 1978-1979 Ford Bronco Trucks, this windshield seal is crafted to fit perfectly and ensure a secure installation. Made from high-quality ozone-resistant EPDM rubber, it is built to last and maintain its shape over time. This seal is installed using the rope-in method and is specifically designed to be used during glass replacement, ensuring a snug and accurate fit. The durable EPDM polymer reduces drafts and road noise, enhancing your driving experience. Its precise seal profile replicates the original specifications, making it an ideal replacement part for restoring your vehicle's functionality and appearance. Backed by a 90-day warranty, this seal is a reliable choice for your restoration or repair project.

Features and Benefits
  • Made from ozone-resistant EPDM rubber for durability.
  • Reduces drafts and road noise for a quieter ride.
  • Designed for a precise fit during glass replacement.
  • Accurate seal profile replicates original specifications.

$190.99
• SALE $152.95
Select Color/Material Options  
1967-1979 Ford F-250 Windshield Weatherstrip Seal, 67-79 Ford Full Size Truck, 78-79 Bronco, Without Trim Groove.
1953-1955 Ford F-250 Door Weatherstrip Seals, 53-55 Ford F-Series Truck, On Body, Pair.

For 1953-1955 Ford F-Series Trucks, these on-body door seals are designed to fit perfectly and protect your truck’s interior from outside elements. Made of durable EPDM polymer, these seals are hollowed out to ensure your doors close smoothly while keeping out drafts, road noise, and weather. They mount directly onto the doors using weatherstrip adhesive (not included), making installation straightforward. These seals are a great fit for 1953-1955 Ford F-100, F-250, and F-350 trucks, ensuring a snug barrier that keeps your climate-controlled air in and the elements out. Backed by a 90-day warranty, this pair of door seals is a reliable solution to restore comfort and protection to your classic truck.

Features and Benefits
  • Keeps out drafts, road noise, and weather.
  • Made of durable EPDM polymer for long-lasting use.
  • Hollowed design ensures doors close properly.
  • Easy installation with weatherstrip adhesive (not included).

$194.49
• SALE $155.95
Select Color/Material Options  
1953-1955 Ford F-250 Door Weatherstrip Seals, 53-55 Ford F-Series Truck, On Body, Pair.
1953-1955 Ford F-250 Vulcanized Windshield Weatherstrip Seal. Each.

For 1953-1955 Ford F-100, F-250, and F-350 trucks, this vulcanized windshield seal is designed to fit perfectly, ensuring a leak-free seal every time. Crafted with high-quality compounds, this seal is built to last for the lifetime of your vehicle, offering durability and reliability you can count on. It installs snugly around the windshield, providing a tight, weatherproof barrier that keeps water and elements out, protecting your truck's interior. This Metro Moulded Parts product is backed by a 30-year warranty, giving you peace of mind for decades to come.

Features and Benefits
  • Creates a perfect, leak-free seal for your windshield.
  • Made with durable, high-quality compounds for long-lasting performance.
  • Protects your truck's interior from water and weather damage.

$194.99
• SALE $155.95
Select Color/Material Options  
1953-1955 Ford F-250 Vulcanized Windshield Weatherstrip Seal. Each.
1961-1966 Ford F-250 Vent Window SL.

This vent window seal is designed specifically for 1961-1966 Ford F150 and F250 trucks. Crafted with precision using the latest advancements in CAD and CNC milling, it ensures a perfect 3D contour and an OEM-quality appearance. This seal fits snugly around the vent window, preventing water, dust, and air leaks, keeping your truck's interior protected from the elements. Its durable material is built to withstand years of use, maintaining its shape and effectiveness over time. Installation is straightforward, as it is designed to fit seamlessly into the original vent window frame, restoring the functionality and look of your classic Ford truck. Backed by Metro Moulded Parts' 90-day No Hassle Guarantee, you can trust in its quality and performance.

Features and Benefits
  • Designed for 1961-1966 Ford F150 and F250 trucks.
  • Prevents water, dust, and air leaks for a sealed interior.
  • Made with advanced CAD and CNC milling for a precise fit.

$198.0
• SALE $158.95
Select Color/Material Options  
1961-1966 Ford F-250 Vent Window SL.

(131 Total Products)