Ford F-350 Weatherstrip & Seals - OEM-Fit Door, Trunk & Window Seals

Stop leaks, drafts, and road noise in your Ford F-350 with precision-fit replacement weatherstrip and seals designed specifically for your vehicle. Each seal is engineered to match the original profile and mounting groove of your Ford F-350—restoring a tight, quiet seal around your doors, trunk, hatch, and windows.

Our Ford F-350 weatherstrip is manufactured from durable, weather-resistant rubber compounds such as EPDM, engineered for an exact OEM-quality fit and finish. These materials resist sunlight, ozone, and chemical exposure while maintaining flexibility across temperature extremes, so your new seals stay soft and pliable instead of cracking or hardening the way factory-original rubber does over time.

Use the Vehicle Selector above to find the correct weatherstrip for your Ford F-350, or browse below to explore available options. Whether you’re chasing down a stubborn water leak or completing a full restoration, Factory Interiors makes it easy to achieve a tight, factory-quality seal with precision-fit weatherstrip for your Ford F-350.

1973-1979 Ford F-350 Driver & Passenger Side Upper Glass Run Channel

OEM-replacement upper glass run channel for the Ford. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.

Replaces Ford: D8TZ1021536A

$14.96
• SALE $10.95
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1973-1979 Ford F-350 Driver & Passenger Side Upper Glass Run Channel
1967-1972 Ford F-350 Driver & Passenger Side Glass Run Division Bar Channel

OEM-replacement glass run division bar channel for the Ford. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.

Replaces Ford: C7TZ8121546A

1953-1955 Ford F-350 Gas Gauge Wire Through Frame. For Sending Unit. 1" O.D.

Designed for 1953-1955 Ford F-100, F-250, and F-350 trucks, this gas gauge wire grommet measures 1" O.D. and is crafted to guide the sending unit wire securely through the frame. Made by Metro Moulded Parts, it features advanced rubber compounds that resist chemicals, sunlight, and ozone, ensuring long-lasting durability in harsh conditions. Its sleek black finish and precise design make it a perfect fit for your classic truck, maintaining both functionality and appearance. Backed by Metro’s 30-year Platinum Warranty, this part guarantees peace of mind for decades.

Features and Benefits
  • Protects the gas gauge wire from wear and damage.
  • Resists harsh environmental factors like sunlight and ozone.
  • Ensures a snug and secure fit for reliable performance.

1953-1956 Ford F-350 Floor Plug Grommet. Used on Each Side of Seat.

Designed for 1953-1956 Ford F-100, F-250, and F-350 trucks, this floor plug grommet fits a 3/4" hole size and is used on each side of the seat to seal and protect openings. Made with state-of-the-art rubber compounds, it is resistant to chemicals, sunlight, and ozone, ensuring long-lasting durability and performance. Its sleek black finish provides a clean, professional look while effectively preventing dirt, moisture, and debris from entering the cabin. Installation is straightforward, as the grommet securely fits into the designated hole, creating a snug and reliable seal. Backed by Metro Moulded Parts' 30-year Platinum Warranty, this part offers peace of mind and confidence in its quality and longevity.

Features and Benefits
  • Fits snugly into 3/4" holes for a secure seal.
  • Protects against dirt, moisture, and debris.
  • Resistant to chemicals, sunlight, and ozone for durability.

1953-1956 Ford F-350 Mirror Hole Plug.

For panel trucks and trucks, this mirror hole plug is designed to fit a 1/2" wide by 1-5/8" long hole, making it a perfect solution for vehicles without side mirrors. Crafted with state-of-the-art rubber compounds, it is resistant to chemicals, sunlight, and ozone, ensuring long-lasting durability and performance. This plug is an excellent fit for 1953-1956 Ford F-100, F-250, and F-350 trucks, providing a clean and seamless look by covering unused mirror holes. Its sleek black finish blends effortlessly with the vehicle's exterior, enhancing its overall appearance. Backed by Metro's Platinum Warranty, this part is protected for 30 years, giving you peace of mind with your purchase.

Features and Benefits
  • Fits securely into 1/2" x 1-5/8" holes for a snug, reliable fit.
  • Made from durable rubber compounds for long-term resistance to wear.
  • Protects against chemical, sunlight, and ozone damage.
  • Enhances the vehicle's appearance by covering unused mirror holes.

(127 Total Products)