Ford F-350 Weatherstrip & Seals - OEM-Fit Door, Trunk & Window Seals

Stop leaks, drafts, and road noise in your Ford F-350 with precision-fit replacement weatherstrip and seals designed specifically for your vehicle. Each seal is engineered to match the original profile and mounting groove of your Ford F-350—restoring a tight, quiet seal around your doors, trunk, hatch, and windows.

Our Ford F-350 weatherstrip is manufactured from durable, weather-resistant rubber compounds such as EPDM, engineered for an exact OEM-quality fit and finish. These materials resist sunlight, ozone, and chemical exposure while maintaining flexibility across temperature extremes, so your new seals stay soft and pliable instead of cracking or hardening the way factory-original rubber does over time.

Use the Vehicle Selector above to find the correct weatherstrip for your Ford F-350, or browse below to explore available options. Whether you’re chasing down a stubborn water leak or completing a full restoration, Factory Interiors makes it easy to achieve a tight, factory-quality seal with precision-fit weatherstrip for your Ford F-350.

1961-1966 Ford F-350 Back Window Seal - Back Window

OEM-replacement back window seal - back window for the Ford. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.

Replaces Ford: C1TB8142084A

$106.44
• SALE $73.95
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1961-1966 Ford F-350 Back Window Seal - Back Window
1971-1972 Ford F-350 Driver & Passenger Side Belt Weatherstrip Kit - Inner & Outer Driver Side & Passenger Side

OEM-replacement belt weatherstrip kit - inner & outer driver side & passenger side for the Ford. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.

Replaces Ford: C7TZ8121452A, C7TZ8121453A, D1TZ1021452A, D1TZ1021453A

$106.44
• SALE $73.95
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1971-1972 Ford F-350 Driver & Passenger Side Belt Weatherstrip Kit - Inner & Outer Driver Side & Passenger Side
1973-1979 Ford F-350 Hood Latch, Non-Locking - Hood

OEM-replacement hood latch, non-locking - hood for the Ford. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.

Replaces Ford: D5UZ16700A

$102.88
• SALE $71.95
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1973-1979 Ford F-350 Hood Latch, Non-Locking - Hood
1980-1986 Ford F-350 Driver & Passenger Side Belt Weatherstrip Kit - Inner & Outer Driver Side & Passenger Side

OEM-replacement belt weatherstrip kit - inner & outer driver side & passenger side for the Ford. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.

Replaces Ford: E0TZ1021452A, E0TZ1021453A, E0TZ1021456A, E0TZ1021457A, EOTZ1021452A, EOTZ1021453A, EOTZ1021456A, EOTZ1021457A

$99.33
• SALE $68.95
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1980-1986 Ford F-350 Driver & Passenger Side Belt Weatherstrip Kit - Inner & Outer Driver Side & Passenger Side
1992-1998 Ford F-350 Driver & Passenger Side Vent Window Seal Kit

OEM-replacement vent window seal kit for the Ford. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.

Replaces Ford: F2TZ 1521408, F2TZ 1521409

$97.53
• SALE $67.95
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1992-1998 Ford F-350 Driver & Passenger Side Vent Window Seal Kit

(127 Total Products)