GMC C2500 Weatherstrip & Seals - OEM-Fit Door, Trunk & Window Seals

Stop leaks, drafts, and road noise in your GMC C2500 with precision-fit replacement weatherstrip and seals designed specifically for your vehicle. Each seal is engineered to match the original profile and mounting groove of your GMC C2500—restoring a tight, quiet seal around your doors, trunk, hatch, and windows.

Our GMC C2500 weatherstrip is manufactured from durable, weather-resistant rubber compounds such as EPDM, engineered for an exact OEM-quality fit and finish. These materials resist sunlight, ozone, and chemical exposure while maintaining flexibility across temperature extremes, so your new seals stay soft and pliable instead of cracking or hardening the way factory-original rubber does over time.

Use the Vehicle Selector above to find the correct weatherstrip for your GMC C2500, or browse below to explore available options. Whether you’re chasing down a stubborn water leak or completing a full restoration, Factory Interiors makes it easy to achieve a tight, factory-quality seal with precision-fit weatherstrip for your GMC C2500.

1979-1986 GMC C2500 Rear Window Weatherstrip Seal, 73-87 GM Full Size Truck.

Designed for 1973-1987 Chevrolet and GMC Pickup Trucks, this rear window seal is crafted to fit perfectly on the body before the glass is installed. Made from durable, ozone-resistant EPDM polymer, it ensures a snug and accurate seal, reducing drafts and road noise while maintaining the original profile and details for a precise fit. This seal is intended for use during glass replacement and features a self-locking strip that secures the glass in place, providing a reliable and long-lasting hold. Please note, this weatherstrip is not compatible with original sliders. Its high-quality construction guarantees a great fit and extended life, making it an essential upgrade for your truck.

Features and Benefits
  • Provides a tight seal to reduce drafts and noise.
  • Made from ozone-resistant EPDM polymer for durability.
  • Designed for easy installation during glass replacement.
  • Maintains original details for a factory-accurate fit.

$101.99
• SALE $81.95
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1979-1986 GMC C2500 Rear Window Weatherstrip Seal, 73-87 GM Full Size Truck.
1999-2000 GMC C2500 Front Door Weatherstrip Seal.

This front door seal, measuring 163.25" long, is designed for Regular/Quad Cab and Extended Cab body styles of '99-'07 Chevrolet Silverado and GMC Sierra C/K 1500/2500 classic trucks, as well as '00-'06 Chevrolet Tahoe, Cadillac Escalade, GMC Denali/Yukon, and '02-'06 Chevrolet Avalanche and Cadillac Escalade extended cabs. It fits the front left-side and right-side on the body for most applications, with specific fitment for the front left-side only on Extended Cabs. Crafted by SUPERsoft, this seal is 30% softer and more durable than other brands, ensuring a snug, weatherproof fit that keeps out moisture, wind, and noise. Unlike other seals, it is made without accelerants or cheap fillers, preventing premature aging and cracking. This part is backed by a 90-day warranty for added peace of mind.

Features and Benefits
  • Provides a tight seal to block out wind, water, and noise.
  • Made with durable, long-lasting materials for extended use.
  • Easy to install on the front doors for a precise fit.
  • Designed to maintain flexibility and performance over time.

$106.99
• SALE $85.95
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1999-2000 GMC C2500 Front Door Weatherstrip Seal.
1979-1991 GMC C2500 Windshield Weatherstrip Seal, 73-87 GM Full Size Truck, 73-91 GM SUV, Without Trim Groove.

This windshield seal is designed for truck body styles and fits a wide range of vehicles, including 1973-1991 Chevrolet and GMC trucks, Blazers, Suburbans, and Jimmys. Made from durable EPDM polymer, this black gasket is crafted to original specifications for a precise fit and long-lasting performance. It installs on the body first, with the glass placed into the opening, and the self-locking strip secures the glass in place. This seal does not include a trim groove, ensuring a clean and seamless appearance. Engineered with high-quality ozone-resistant materials, it guarantees a perfect seal that prevents leaks, reduces drafts, and minimizes road noise. Designed for installation during glass replacement, it ensures your vehicle stays protected and comfortable. Backed by a 90-day warranty, this part is a reliable choice for restoring or maintaining your truck.

Features and Benefits
  • Provides a precise and leak-proof seal.
  • Reduces drafts and road noise for a quieter ride.
  • Made from ozone-resistant materials for long-lasting durability.
  • Easy installation during glass replacement.

$108.49
• SALE $86.95
Select Color/Material Options  
1979-1991 GMC C2500 Windshield Weatherstrip Seal, 73-87 GM Full Size Truck, 73-91 GM SUV, Without Trim Groove.
1999-2000 GMC C2500 Front Door Weatherstrip Seal. Right Side Only.

This front door seal is designed for extended cab trucks and SUVs, specifically fitting the front right side of 1999-2007 Chevrolet Silverado and GMC Sierra C/K 1500/2500 classic extended cab models, as well as 2000-2006 Chevrolet Suburban and GMC Denali XL/Yukon XL models. Measuring 221.5" in length with a 3/4" outer diameter bulb and a 1/2" outer diameter pinch, this seal ensures a precise fit and excellent sealing performance. Crafted by SUPERsoft, it is 30% softer and more durable than other brands, providing a snug, weatherproof barrier against wind, rain, and noise. Unlike other seals, it is made without accelerants or cheap fillers, ensuring long-lasting performance without premature aging or cracking. Installation is straightforward, as the seal is designed to fit securely onto the body of the vehicle, restoring the original factory seal and enhancing comfort and protection. Backed by a 90-day warranty, this part is a reliable choice for maintaining your vehicle's integrity.

Features and Benefits
  • Provides a tight seal to block wind, rain, and noise.
  • Made with durable, high-quality materials for long-lasting use.
  • Easy to install for a secure fit on the front right side.
  • Designed to maintain factory-like performance and comfort.

$123.99
• SALE $98.95
Select Color/Material Options  
1999-2000 GMC C2500 Front Door Weatherstrip Seal. Right Side Only.
1999-2000 GMC C2500 Rear Door Weatherstrip Seal.

This rear door seal is designed for Quad Cab trucks and SUVs, fitting the rear left and right sides of the body for '99-'07 Chevrolet Silverado and GMC Sierra C/K 1500/2500 classic models, '00-'06 Chevrolet Suburban, GMC Denali XL/Yukon XL, and '02-'06 Chevrolet Avalanche and Cadillac Escalade. Crafted by SUPERsoft, this seal is 30% softer and more durable than other brands, ensuring a snug fit and long-lasting performance. It is molded without accelerants or cheap fillers, preventing premature aging or cracking. This seal is perfect for keeping out water, dust, and noise, maintaining a comfortable and quiet cabin environment. Installation is straightforward, as it fits directly onto the designated door areas. Backed by SUPERsoft’s 30-year warranty, this part guarantees reliability and peace of mind.

Features and Benefits
  • Keeps water, dust, and noise out for a quieter ride.
  • Made with premium materials for durability and flexibility.
  • Easy to install with a precise fit for listed models.

$135.49
• SALE $108.95
Select Color/Material Options  
1999-2000 GMC C2500 Rear Door Weatherstrip Seal.

(15 Total Products)