GMC C2500 Weatherstrip & Seals - OEM-Fit Door, Trunk & Window Seals

Stop leaks, drafts, and road noise in your GMC C2500 with precision-fit replacement weatherstrip and seals designed specifically for your vehicle. Each seal is engineered to match the original profile and mounting groove of your GMC C2500—restoring a tight, quiet seal around your doors, trunk, hatch, and windows.

Our GMC C2500 weatherstrip is manufactured from durable, weather-resistant rubber compounds such as EPDM, engineered for an exact OEM-quality fit and finish. These materials resist sunlight, ozone, and chemical exposure while maintaining flexibility across temperature extremes, so your new seals stay soft and pliable instead of cracking or hardening the way factory-original rubber does over time.

Use the Vehicle Selector above to find the correct weatherstrip for your GMC C2500, or browse below to explore available options. Whether you’re chasing down a stubborn water leak or completing a full restoration, Factory Interiors makes it easy to achieve a tight, factory-quality seal with precision-fit weatherstrip for your GMC C2500.

1979-1980 GMC C2500 Vent Window Weatherstrip Seal,73-80 GM Truck and SUV, Set of Four.

Designed for 1973-1980 Chevrolet and GMC trucks, this 4-piece vent window seal set is crafted to fit models like the Blazer, Suburban, C10, K10, and Jimmy. Made from high-quality, ozone-resistant EPDM rubber, these seals are precision-engineered to replace both the driver and passenger vent window seals, as well as the rear division channel seals. Built to original specifications, they ensure a snug fit, keeping out weather, drafts, and road noise while maintaining your vehicle's climate-controlled interior. The durable EPDM polymer construction offers long-lasting performance, making it a reliable choice for restoring your truck's comfort and functionality. Backed by a 90-day warranty, this set is a hassle-free solution for enhancing your truck's weatherproofing and reducing noise.

Features and Benefits
  • Keeps out weather and drafts for a quieter ride.
  • Made from durable, ozone-resistant EPDM rubber.
  • Restores a precise seal for climate control.
  • Designed for a perfect fit on 1973-1980 Chevrolet and GMC trucks.

$177.99
• SALE $142.95
Select Color/Material Options  
1979-1980 GMC C2500 Vent Window Weatherstrip Seal,73-80 GM Truck and SUV, Set of Four.
1981-1985 GMC C2500 Vent Window Weatherstrip Seal, 81-85 GM Full Size Truck, GMC Jimmy, 85-91 Chevy Blazer.

Designed for 1981-1991 Chevrolet and GMC trucks and Suburbans, this 4-piece weatherstrip set is crafted to replace the vent window seals and rear division channel seals on both the driver and passenger doors. This set features the two-piece per side design, so be sure to confirm compatibility with your vehicle before purchase. Made from high-quality, ozone-resistant EPDM rubber, these seals are built to original specifications for a precise fit and long-lasting durability. They effectively block out weather, drafts, and road noise while keeping your climate-controlled air inside, ensuring a quieter and more comfortable ride. The durable EPDM polymer construction resists wear and tear, providing reliable protection against the elements. This set is a perfect fit for a wide range of models, including Chevrolet C10, C20, C30, K10, K20, K30, Blazer, and Suburban trucks, as well as GMC C1500, C2500, C3500, K1500, K2500, K3500, Jimmy, and Suburban trucks from 1981 to 1991. Backed by a 90-day warranty, this set offers peace of mind with its no-hassle replacement guarantee.

Features and Benefits
  • Keeps out weather and reduces road noise for a quieter ride.
  • Made from ozone-resistant EPDM rubber for long-lasting durability.
  • Designed to original specs for a precise fit and easy installation.
  • Protects your interior while maintaining climate control efficiency.

$207.49
• SALE $165.95
Select Color/Material Options  
1981-1985 GMC C2500 Vent Window Weatherstrip Seal, 81-85 GM Full Size Truck, GMC Jimmy, 85-91 Chevy Blazer.
1979-1980 GMC C2500 Window Channel and Sweeper Kit, for Front Doors.

Window Channel and Sweeper Kit, for Front Doors. 6-Piece Kit

Features and Benefits
  • Superior form and function
  • Accurate seal profiles

$392.99
• SALE $313.95
Select Color/Material Options  
1979-1980 GMC C2500 Window Channel and Sweeper Kit, for Front Doors.
1981-1986 GMC C2500 Window Channel and Sweeper Kit 6-Piece Kit.

Window Channel and Sweeper Kit 6-Piece Kit

Features and Benefits
  • Superior form and function
  • Accurate seal profiles

$392.99
• SALE $313.95
Select Color/Material Options  
1981-1986 GMC C2500 Window Channel and Sweeper Kit 6-Piece Kit.
1979-1986 GMC C2500 Window Channel and Sweeper Kit, for Front Doors.

Window Channel and Sweeper Kit, for Front Doors. 6-Piece Kit

Features and Benefits
  • Superior form and function
  • Accurate seal profiles

$392.99
• SALE $313.95
Select Color/Material Options  
1979-1986 GMC C2500 Window Channel and Sweeper Kit, for Front Doors.

(15 Total Products)