GMC Sierra 2500 Weatherstrip & Seals - OEM-Fit Door, Trunk & Window Seals
Stop leaks, drafts, and road noise in your GMC Sierra 2500 with precision-fit replacement weatherstrip and seals designed specifically for your vehicle. Each seal is engineered to match the original profile and mounting groove of your GMC Sierra 2500—restoring a tight, quiet seal around your doors, trunk, hatch, and windows.
Our GMC Sierra 2500 weatherstrip is manufactured from durable, weather-resistant rubber compounds such as EPDM, engineered for an exact OEM-quality fit and finish. These materials resist sunlight, ozone, and chemical exposure while maintaining flexibility across temperature extremes, so your new seals stay soft and pliable instead of cracking or hardening the way factory-original rubber does over time.
Use the Vehicle Selector above to find the correct weatherstrip for your GMC Sierra 2500, or browse below to explore available options. Whether you’re chasing down a stubborn water leak or completing a full restoration, Factory Interiors makes it easy to achieve a tight, factory-quality seal with precision-fit weatherstrip for your GMC Sierra 2500.
This front door seal, measuring 163.25" long, is designed for Regular/Quad Cab and Extended Cab body styles of '99-'07 Chevrolet Silverado and GMC Sierra C/K 1500/2500 classic trucks, as well as '00-'06 Chevrolet Tahoe, Cadillac Escalade, GMC Denali/Yukon, and '02-'06 Chevrolet Avalanche and Cadillac Escalade extended cabs. It fits the front left-side and right-side on the body for most applications, with specific fitment for the front left-side only on Extended Cabs. Crafted by SUPERsoft, this seal is 30% softer and more durable than other brands, ensuring a snug, weatherproof fit that keeps out moisture, wind, and noise. Unlike other seals, it is made without accelerants or cheap fillers, preventing premature aging and cracking. This part is backed by a 90-day warranty for added peace of mind.
Features and Benefits- Provides a tight seal to block out wind, water, and noise.
- Made with durable, long-lasting materials for extended use.
- Easy to install on the front doors for a precise fit.
- Designed to maintain flexibility and performance over time.
This front door seal is designed for extended cab trucks and SUVs, specifically fitting the front right side of 1999-2007 Chevrolet Silverado and GMC Sierra C/K 1500/2500 classic extended cab models, as well as 2000-2006 Chevrolet Suburban and GMC Denali XL/Yukon XL models. Measuring 221.5" in length with a 3/4" outer diameter bulb and a 1/2" outer diameter pinch, this seal ensures a precise fit and excellent sealing performance. Crafted by SUPERsoft, it is 30% softer and more durable than other brands, providing a snug, weatherproof barrier against wind, rain, and noise. Unlike other seals, it is made without accelerants or cheap fillers, ensuring long-lasting performance without premature aging or cracking. Installation is straightforward, as the seal is designed to fit securely onto the body of the vehicle, restoring the original factory seal and enhancing comfort and protection. Backed by a 90-day warranty, this part is a reliable choice for maintaining your vehicle's integrity.
Features and Benefits- Provides a tight seal to block wind, rain, and noise.
- Made with durable, high-quality materials for long-lasting use.
- Easy to install for a secure fit on the front right side.
- Designed to maintain factory-like performance and comfort.
This rear door seal is designed for Quad Cab trucks and SUVs, fitting the rear left and right sides of the body for '99-'07 Chevrolet Silverado and GMC Sierra C/K 1500/2500 classic models, '00-'06 Chevrolet Suburban, GMC Denali XL/Yukon XL, and '02-'06 Chevrolet Avalanche and Cadillac Escalade. Crafted by SUPERsoft, this seal is 30% softer and more durable than other brands, ensuring a snug fit and long-lasting performance. It is molded without accelerants or cheap fillers, preventing premature aging or cracking. This seal is perfect for keeping out water, dust, and noise, maintaining a comfortable and quiet cabin environment. Installation is straightforward, as it fits directly onto the designated door areas. Backed by SUPERsoft’s 30-year warranty, this part guarantees reliability and peace of mind.
Features and Benefits- Keeps water, dust, and noise out for a quieter ride.
- Made with premium materials for durability and flexibility.
- Easy to install with a precise fit for listed models.
Designed for trucks and SUVs, this door seal fits 2007-2014 Chevrolet Avalanche, Silverado, Suburban, and Tahoe models, as well as GMC Sierra, Yukon, and Yukon XL vehicles, including Cadillac Escalade series from the same years. Made of durable EPDM polymer, this seal ensures a snug fit for front or rear door openings, left or right side, and mounts directly on the body. Its accurate seal profile effectively reduces drafts and road noise, enhancing cabin comfort. With an OEM fit at a fraction of the cost, it’s a reliable replacement that restores your vehicle’s weatherproofing and soundproofing. Backed by a 90-day hassle-free warranty, this part is a practical and affordable solution for maintaining your vehicle’s performance and comfort.
Features and Benefits- Provides a tight seal to block drafts and noise.
- Made from durable EPDM polymer for long-lasting use.
- Fits front or rear doors, left or right side, on body.
- Easy installation with OEM fit for a seamless replacement.
For extended cab GM full-size trucks from 2000 to 2007, this upper door seal pair (OEM #15054569 & #15044908) is designed to mount on the body and seal against the doors, ensuring a snug fit. Made from high-quality, ozone-resistant EPDM rubber, these seals are built to last and maintain their flexibility over time. They feature an accurate seal profile and incorporate all original details for a precise fit, reducing drafts and road noise for a quieter and more comfortable ride. This pair includes seals for both the left and right sides, making installation straightforward and ensuring complete coverage. Compatible with Chevrolet Silverado and GMC Sierra models from 2000 to 2007, including Classic editions, this part is a reliable replacement for worn or damaged seals. Backed by a 90-day warranty, this product ensures peace of mind with its durability and performance.
Features and Benefits- Reduces drafts and road noise for a quieter cabin.
- Made from durable, ozone-resistant EPDM rubber for long-lasting use.
- Designed for a precise fit with accurate seal profiles.
- Easy installation with seals for both left and right sides included.
(27 Total Products)