GMC Sierra 3500 Weatherstrip & Seals - OEM-Fit Door, Trunk & Window Seals

Stop leaks, drafts, and road noise in your GMC Sierra 3500 with precision-fit replacement weatherstrip and seals designed specifically for your vehicle. Each seal is engineered to match the original profile and mounting groove of your GMC Sierra 3500—restoring a tight, quiet seal around your doors, trunk, hatch, and windows.

Our GMC Sierra 3500 weatherstrip is manufactured from durable, weather-resistant rubber compounds such as EPDM, engineered for an exact OEM-quality fit and finish. These materials resist sunlight, ozone, and chemical exposure while maintaining flexibility across temperature extremes, so your new seals stay soft and pliable instead of cracking or hardening the way factory-original rubber does over time.

Use the Vehicle Selector above to find the correct weatherstrip for your GMC Sierra 3500, or browse below to explore available options. Whether you’re chasing down a stubborn water leak or completing a full restoration, Factory Interiors makes it easy to achieve a tight, factory-quality seal with precision-fit weatherstrip for your GMC Sierra 3500.

2001-2006 GMC Sierra 3500 Driver & Passenger Side Door Seal

OEM-replacement door seal for Cadillac / Chevrolet / GMC. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.

Replaces GM: 15752299

$45.37
• SALE $31.95
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2001-2006 GMC Sierra 3500 Driver & Passenger Side Door Seal
2001-2002 GMC Sierra 3500 Driver & Passenger Side Belt Weatherstrip Kit

OEM-replacement belt weatherstrip kit for Chevrolet / GMC. Precision-molded from EPDM rubber to resist UV, heat, ozone, and moisture — restoring the factory seal and eliminating wind noise, water leaks, and drafts.

Replaces GM: 15704112, 15735502

$20.17
• SALE $13.95
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2001-2002 GMC Sierra 3500 Driver & Passenger Side Belt Weatherstrip Kit
2007-2013 GMC Sierra 3500 Door Weatherstrip Seal, 07-13 GM Standard, Crew Cab Trucks and 4 Door Sport Utility Vehicles.

Designed for trucks and SUVs, this door seal fits 2007-2014 Chevrolet Avalanche, Silverado, Suburban, and Tahoe models, as well as GMC Sierra, Yukon, and Yukon XL vehicles, including Cadillac Escalade series from the same years. Made of durable EPDM polymer, this seal ensures a snug fit for front or rear door openings, left or right side, and mounts directly on the body. Its accurate seal profile effectively reduces drafts and road noise, enhancing cabin comfort. With an OEM fit at a fraction of the cost, it’s a reliable replacement that restores your vehicle’s weatherproofing and soundproofing. Backed by a 90-day hassle-free warranty, this part is a practical and affordable solution for maintaining your vehicle’s performance and comfort.

Features and Benefits
  • Provides a tight seal to block drafts and noise.
  • Made from durable EPDM polymer for long-lasting use.
  • Fits front or rear doors, left or right side, on body.
  • Easy installation with OEM fit for a seamless replacement.

$141.49
• SALE $112.95
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2007-2013 GMC Sierra 3500 Door Weatherstrip Seal, 07-13 GM Standard, Crew Cab Trucks and 4 Door Sport Utility Vehicles.
2007-2013 GMC Sierra 3500 Door Weatherstrip Seal, 07-13 GM Full Size Extended Cab Truck, Fits Right Side Only, on Body.

Designed for extended cab truck models, this door seal fits the right side of 2007-2013 Chevrolet Silverado and GMC Sierra 1500/2500/2500HD/3500HD vehicles, attaching securely to the body for a precise fit. Made from durable EPDM polymer, this seal is crafted to reduce drafts and road noise, ensuring a quieter and more comfortable ride. Its accurate seal profile guarantees an OEM-quality fit at a fraction of the cost, making it a reliable and cost-effective replacement. Backed by SuperSoft's 30-year warranty, you can trust this part to perform for the long haul.

Features and Benefits
  • Reduces drafts and road noise for a quieter cabin.
  • Made from durable EPDM polymer for long-lasting performance.
  • Accurate seal profile ensures a snug, OEM-quality fit.

$166.99
• SALE $133.95
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2007-2013 GMC Sierra 3500 Door Weatherstrip Seal, 07-13 GM Full Size Extended Cab Truck, Fits Right Side Only, on Body.
2007-2013 GMC Sierra 3500 Door Weatherstrip Seal, 07-13 GM Full Size Extended Cab Trucks, Fits Left Side Only, on Body.

Designed for extended cab truck models, this door seal fits the left side of 2007-2013 Chevrolet Silverado and GMC Sierra 1500/2500/2500HD/3500HD vehicles. Made from durable EPDM polymer, it ensures a precise OEM fit at a fraction of the cost. This seal installs on the body of the truck, providing an accurate profile that effectively reduces drafts and road noise, enhancing cabin comfort. Its robust construction is built to withstand the elements, offering long-lasting performance. Backed by a 30-year warranty from SuperSoft, you can trust this part to deliver reliable protection and peace of mind for years to come.

Features and Benefits
  • Reduces drafts and road noise for a quieter ride.
  • Made from durable EPDM polymer for long-lasting use.
  • Provides an accurate OEM fit for easy installation.

$202.49
• SALE $161.95
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2007-2013 GMC Sierra 3500 Door Weatherstrip Seal, 07-13 GM Full Size Extended Cab Trucks, Fits Left Side Only, on Body.

(20 Total Products)