Ford F-350 Weatherstrip & Seals - OEM-Fit Door, Trunk & Window Seals

Stop leaks, drafts, and road noise in your Ford F-350 with precision-fit replacement weatherstrip and seals designed specifically for your vehicle. Each seal is engineered to match the original profile and mounting groove of your Ford F-350—restoring a tight, quiet seal around your doors, trunk, hatch, and windows.

Our Ford F-350 weatherstrip is manufactured from durable, weather-resistant rubber compounds such as EPDM, engineered for an exact OEM-quality fit and finish. These materials resist sunlight, ozone, and chemical exposure while maintaining flexibility across temperature extremes, so your new seals stay soft and pliable instead of cracking or hardening the way factory-original rubber does over time.

Use the Vehicle Selector above to find the correct weatherstrip for your Ford F-350, or browse below to explore available options. Whether you’re chasing down a stubborn water leak or completing a full restoration, Factory Interiors makes it easy to achieve a tight, factory-quality seal with precision-fit weatherstrip for your Ford F-350.

1977-1979 Ford F-350 Windshield Lockstrip Weatherstrip Seal, '77-'79 Ford F Series Truck / '78-'79 Ford Bronco.

Designed for the 1977-1979 Ford F-Series Trucks and 1978-1979 Ford Bronco, this windshield lockstrip seal ensures a snug and secure fit for your vehicle's windshield. Crafted from durable EPDM polymer, it offers excellent resistance to weather, UV rays, and wear, making it a reliable choice for long-term use. The seal features an accurate profile that matches the original design, ensuring a seamless installation and a clean, factory-like appearance. This part is specifically made to fit 1977-1979 Ford F-100, F-150, F-250, and F-350 trucks, as well as 1978-1979 Ford Broncos, providing a perfect fit for these models. Backed by a 90-day warranty, this lockstrip seal is a dependable solution to keep your windshield securely in place while protecting against leaks and drafts.

Features and Benefits
  • Made from durable EPDM polymer for long-lasting performance.
  • Provides a precise fit for 1977-1979 Ford F-Series Trucks and 1978-1979 Ford Broncos.
  • Protects against weather, drafts, and leaks.
  • Easy to install with a clean, factory-like finish.

$52.99
• SALE $42.95
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1977-1979 Ford F-350 Windshield Lockstrip Weatherstrip Seal, '77-'79 Ford F Series Truck / '78-'79 Ford Bronco.
1953-1964 Ford F-350 Rear Roll-Up Weatherstrip Seal. Two 18" Sections Sliced Into Metal Track.

For classic Ford cars and trucks, this rear roll-up seal is designed to fit models from 1946 to 1964, including Deluxe, Super Deluxe, Custom, Crestline, Thunderbird, and F-series trucks. Measuring two 18-inch sections, this seal is sliced into a metal track and crafted without a steel insert for easy installation. Made from advanced rubber compounds, it resists sunlight, ozone, and chemicals, ensuring long-lasting durability. Unlike cheaper alternatives, Metro Moulded Parts avoids using accelerants or fillers, preventing premature aging or failure. This seal is a perfect fit for restoring your vehicle's weatherproofing, keeping out moisture and debris while maintaining a clean, polished look. Backed by Metro's 30-year warranty, you can trust this part to perform for decades.

Features and Benefits
  • Protects against moisture and debris for a weatherproof seal.
  • Made with high-quality rubber compounds for durability.
  • Easy installation with a sliced metal track design.

$54.99
• SALE $43.95
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1953-1964 Ford F-350 Rear Roll-Up Weatherstrip Seal. Two 18" Sections Sliced Into Metal Track.
1967-1972 Ford F-350 Door Weatherstrip Seal. Fits Either Side. Each.

This door seal is designed for 1967-1972 Ford F-100, F-250, and F-350 trucks, fitting either side of the vehicle. Crafted by SUPERsoft, it is 30% softer and more durable than other brands, ensuring a snug fit and long-lasting performance. The seal is made without accelerants or cheap fillers, which prevents premature aging and cracking, keeping your truck protected from drafts, water leaks, and road noise. Its flexible design makes installation straightforward, conforming perfectly to the door frame for a tight seal. Backed by a 30-year warranty, this SUPERsoft part guarantees peace of mind and exceptional quality for decades.

Features and Benefits
  • Provides a tight seal to block water, drafts, and noise.
  • Made with premium materials to resist aging and cracking.
  • Easy to install with a flexible, durable design.

$60.99
• SALE $48.95
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1967-1972 Ford F-350 Door Weatherstrip Seal. Fits Either Side. Each.
1973-1979 Ford F-350 Upper Door Weatherstrip Seal, 73-79 Ford Full Size Truck, 78-79 Ford Bronco, On Door, Pair.

Designed for 1973-1979 Ford F-100, F-250, and F-350 trucks, this auxiliary door seal fits the top portion of the door and is crafted to reduce wind and road noise while enhancing weather protection. Made from durable EPDM polymer, it features an accurate seal profile that cushions the door when closed, ensuring a snug fit and added comfort. Originally stock on 1978-1979 models, it is compatible with all 1973-1979 models listed, offering a versatile solution for restoring or upgrading your truck's weatherproofing. This seal is easy to install, providing a seamless fit that enhances the driving experience by minimizing drafts and noise. Backed by a 90-day warranty, it guarantees peace of mind with its reliable performance and quality construction.

Features and Benefits
  • Reduces wind and road noise for a quieter ride.
  • Enhances weather protection to keep the interior dry.
  • Made from durable EPDM polymer for long-lasting use.
  • Easy installation ensures a snug and accurate fit.

$61.49
• SALE $49.95
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1973-1979 Ford F-350 Upper Door Weatherstrip Seal, 73-79 Ford Full Size Truck, 78-79 Ford Bronco, On Door, Pair.
1956 Ford F-350 Weatherstrip Seals. Used at Back of Cab. 2-3/8" X 9-3/4". Pair.

Weatherseals. Used at back of cab. 2-3/8" X 9-3/4". Pair

Features and Benefits
  • Concours quality details
  • Easy to install

$69.99
• SALE $55.95
Select Color/Material Options  
1956 Ford F-350 Weatherstrip Seals. Used at Back of Cab. 2-3/8" X 9-3/4". Pair.

(127 Total Products)