Ford F-350 Weatherstrip & Seals - OEM-Fit Door, Trunk & Window Seals

Stop leaks, drafts, and road noise in your Ford F-350 with precision-fit replacement weatherstrip and seals designed specifically for your vehicle. Each seal is engineered to match the original profile and mounting groove of your Ford F-350—restoring a tight, quiet seal around your doors, trunk, hatch, and windows.

Our Ford F-350 weatherstrip is manufactured from durable, weather-resistant rubber compounds such as EPDM, engineered for an exact OEM-quality fit and finish. These materials resist sunlight, ozone, and chemical exposure while maintaining flexibility across temperature extremes, so your new seals stay soft and pliable instead of cracking or hardening the way factory-original rubber does over time.

Use the Vehicle Selector above to find the correct weatherstrip for your Ford F-350, or browse below to explore available options. Whether you’re chasing down a stubborn water leak or completing a full restoration, Factory Interiors makes it easy to achieve a tight, factory-quality seal with precision-fit weatherstrip for your Ford F-350.

1977-1979 Ford F-350 Windshield Weatherstrip Seal with Trim Groove 77-79 Ford F Series Truck 78-79 Ford Bronco.

Designed for the 1977-1979 Ford F-Series Trucks and 1978-1979 Ford Bronco, this windshield seal with Trim Groove is crafted to provide a precise fit and exceptional durability. Made from high-quality EPDM polymer, it features a groove to securely accept trim, ensuring a clean and professional finish. This seal is engineered to reduce drafts and road noise, enhancing the comfort of your ride. Its accurate profile ensures a snug fit, making installation straightforward while maintaining a tight seal to keep out water and debris. Whether you're restoring a classic or maintaining your vehicle, this seal is a reliable choice for keeping your windshield secure and your cabin quiet.

Features and Benefits
  • Made from durable EPDM polymer for long-lasting performance.
  • Reduces drafts and road noise for a quieter ride.
  • Features a groove to accept trim for a clean, finished look.
  • Designed for easy installation with an accurate seal profile.

$173.99
• SALE $138.95
Select Color/Material Options  
1977-1979 Ford F-350 Windshield Weatherstrip Seal with Trim Groove 77-79 Ford F Series Truck 78-79 Ford Bronco.
1973-1976 Ford F-350 Windshield Weatherstrip Seal, '73-'76 Ford F Series Truck.

For 1973-1976 Ford F-Series Trucks, this windshield seal is designed specifically for models like the F-100, F-150, F-250, and F-350, ensuring a precise fit for these classic pickups. Made from durable EPDM polymer, this seal features a groove to accommodate trim, making it both functional and visually seamless. Its accurate profile helps reduce drafts and road noise, enhancing the driving experience while protecting the interior from the elements. This seal is built to last, offering excellent resistance to weathering and wear. Installation is straightforward, as it fits snugly around the windshield, providing a secure and reliable seal. Backed by a 90-day warranty, this part ensures peace of mind with its quality and performance.

Features and Benefits
  • Fits 1973-1976 Ford F-Series Trucks for a perfect match.
  • Made from durable EPDM polymer for long-lasting performance.
  • Reduces drafts and road noise for a quieter ride.
  • Includes a groove to accept trim, ensuring a clean and polished look.

$174.99
• SALE $139.95
Select Color/Material Options  
1973-1976 Ford F-350 Windshield Weatherstrip Seal, '73-'76 Ford F Series Truck.
1956 Ford F-350 Door Weatherstrip Seal, 56 Ford Full Size Pickup Trucks, On Body, Pair.

For 1956 Ford F-100, F-250, and F-350 trucks, this durable door weatherstrip is designed to protect your truck’s interior from outside elements while reducing road noise. Made from tough EPDM polymer, it features a hollowed-out design that ensures your doors close properly, unlike solid sponge alternatives. This weatherstrip mounts directly onto the door using weatherstrip adhesive (not included), creating an accurate seal profile that keeps water, dust, and wind out. Its sleek black finish complements the classic look of your truck while providing long-lasting performance. Backed by a 90-day warranty, this weatherstrip is a reliable solution for restoring comfort and protection to your vintage Ford truck.

Features and Benefits
  • Protects your truck’s interior from water, dust, and wind.
  • Reduces noise for a quieter ride.
  • Hollowed-out design ensures proper door closure.
  • Made from durable EPDM polymer for long-lasting use.

$177.49
• SALE $141.95
Select Color/Material Options  
1956 Ford F-350 Door Weatherstrip Seal, 56 Ford Full Size Pickup Trucks, On Body, Pair.
1953-1960 Ford F-350 Flexible Window Sweeper. Made with Stainless Steel Bead.

Flexible window sweeper. Made with stainless steel bead. 96 in. long. Each. NOTE: $20 special shipping charge applies for domestic orders. Call or email for overseas shipping costs. Part can be sectioned in two or three equal lengths to reduce overseas shipping costs.

Features and Benefits
  • Superior form and function
  • Accurate seal profiles

$177.49
• SALE $141.95
Select Color/Material Options  
1953-1960 Ford F-350 Flexible Window Sweeper. Made with Stainless Steel Bead.
1967-1972 Ford F-350 Rear Window Weatherstrip Seal, 67-72 Ford Full Size Truck, Without Trim Groove, Each.

For 1967-1972 Ford F-100, F-250, and F-350 trucks, this rear window seal is crafted to fit perfectly and ensure long-lasting performance. Designed to be installed during glass replacement, this black gasket is made from durable EPDM polymer and follows the original specifications for a precise fit. It is ozone-resistant, ensuring it withstands harsh weather conditions while reducing drafts and road noise for a quieter ride. The seal is installed directly onto the body before placing the glass into the opening, providing a secure and accurate seal without a trim groove. This part is a reliable choice for maintaining the integrity of your truck's rear window and enhancing its overall comfort and durability.

Features and Benefits
  • Made from high-quality ozone-resistant EPDM polymer.
  • Reduces drafts and road noise for a quieter cabin.
  • Designed for easy installation during glass replacement.
  • Ensures a precise fit with accurate seal profiles.

$179.49
• SALE $143.95
Select Color/Material Options  
1967-1972 Ford F-350 Rear Window Weatherstrip Seal, 67-72 Ford Full Size Truck, Without Trim Groove, Each.

(127 Total Products)